Rate of 6‐[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease
Identifieur interne : 000175 ( Main/Exploration ); précédent : 000174; suivant : 000176Rate of 6‐[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease
Auteurs : Catherine L. Gallagher [États-Unis] ; Terrence R. Oakes [États-Unis] ; Sterling C. Johnson [États-Unis] ; Moo K. Chung [États-Unis] ; James E. Holden [États-Unis] ; Barbara B. Bendlin [États-Unis] ; Donald G. Mclaren [États-Unis] ; Guofan Xu [États-Unis] ; Robert J. Nickles [États-Unis] ; Robert Pyzalski [États-Unis] ; Onofre Dejesus [États-Unis] ; W. Douglas Brown [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
- KwdEn :
Abstract
Background:: Rate of decline in 6‐L‐[18F]fluorodopa (FDOPA) uptake within the striatum has been reported as showing regional differences in Parkinson's disease (PD). Methods:: We acquired longitudinal brain FDOPA positron emission tomography (PET) studies in 26 PD subjects and 11 controls over 4.5 years. We analyzed both spatially normalized voxel‐wise maps of radiotracer influx (Kocc) and average Kocc values for six non‐overlapping volumes of interest (VOIs) encompassing the striatum. Results:: The voxel‐wise analysis showed that in PD, FDOPA Kocc decline spanned the striatum but was greatest in the posterior putamen ipsilateral and anterior putamen contralateral to initial symptoms. The VOI approached showed that absolute rates of Kocc decline were significantly greater in PD than control subjects, but that the slope of decline did not differ between subregions. In PD, ratios of uptake between subregions did not change during the study with the exception of the ipsilateral putamen/caudate ratio. Decline rates were marginally greater during earlier time segments. Both male gender and advancing age were associated with lower baseline FDOPA uptake, but no difference in decline rates. VOI Kocc values were significantly correlated with disease duration, but only moderately correlated with clinical measures. Discussion:: We conclude that FDOPA uptake in subregions of the striatum is strongly correlated with disease duration and age, and declines approximately equally from symptom onset in PD. This implies that in idiopathic PD, relative preservation of uptake in the anterior striatum reflects a delay in pathologic involvement of nigrostriatal projections to this region. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23503
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rate of 6‐[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease</title><author><name sortKey="Gallagher, Catherine L" sort="Gallagher, Catherine L" uniqKey="Gallagher C" first="Catherine L." last="Gallagher">Catherine L. Gallagher</name></author><author><name sortKey="Oakes, Terrence R" sort="Oakes, Terrence R" uniqKey="Oakes T" first="Terrence R." last="Oakes">Terrence R. Oakes</name></author><author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C." last="Johnson">Sterling C. Johnson</name></author><author><name sortKey="Chung, Moo K" sort="Chung, Moo K" uniqKey="Chung M" first="Moo K." last="Chung">Moo K. Chung</name></author><author><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E." last="Holden">James E. Holden</name></author><author><name sortKey="Bendlin, Barbara B" sort="Bendlin, Barbara B" uniqKey="Bendlin B" first="Barbara B." last="Bendlin">Barbara B. Bendlin</name></author><author><name sortKey="Mclaren, Donald G" sort="Mclaren, Donald G" uniqKey="Mclaren D" first="Donald G." last="Mclaren">Donald G. Mclaren</name></author><author><name sortKey="Xu, Guofan" sort="Xu, Guofan" uniqKey="Xu G" first="Guofan" last="Xu">Guofan Xu</name></author><author><name sortKey="Nickles, Robert J" sort="Nickles, Robert J" uniqKey="Nickles R" first="Robert J." last="Nickles">Robert J. Nickles</name></author><author><name sortKey="Pyzalski, Robert" sort="Pyzalski, Robert" uniqKey="Pyzalski R" first="Robert" last="Pyzalski">Robert Pyzalski</name></author><author><name sortKey="Dejesus, Onofre" sort="Dejesus, Onofre" uniqKey="Dejesus O" first="Onofre" last="Dejesus">Onofre Dejesus</name></author><author><name sortKey="Brown, W Douglas" sort="Brown, W Douglas" uniqKey="Brown W" first="W. Douglas" last="Brown">W. Douglas Brown</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D04619D25D6B2071F8A6C7A36FA7EEAAF0A328C7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23503</idno><idno type="url">https://api.istex.fr/document/D04619D25D6B2071F8A6C7A36FA7EEAAF0A328C7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C40</idno><idno type="wicri:Area/Main/Curation">000A89</idno><idno type="wicri:Area/Main/Exploration">000175</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Rate of 6‐[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease</title><author><name sortKey="Gallagher, Catherine L" sort="Gallagher, Catherine L" uniqKey="Gallagher C" first="Catherine L." last="Gallagher">Catherine L. Gallagher</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Oakes, Terrence R" sort="Oakes, Terrence R" uniqKey="Oakes T" first="Terrence R." last="Oakes">Terrence R. Oakes</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Waisman Center Brain Imaging Laboratory, University of Wisconsin, Madison</wicri:regionArea><wicri:noRegion>Madison</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C." last="Johnson">Sterling C. Johnson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Chung, Moo K" sort="Chung, Moo K" uniqKey="Chung M" first="Moo K." last="Chung">Moo K. Chung</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Waisman Center Brain Imaging Laboratory, University of Wisconsin, Madison</wicri:regionArea><wicri:noRegion>Madison</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E." last="Holden">James E. Holden</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Physics, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Bendlin, Barbara B" sort="Bendlin, Barbara B" uniqKey="Bendlin B" first="Barbara B." last="Bendlin">Barbara B. Bendlin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Mclaren, Donald G" sort="Mclaren, Donald G" uniqKey="Mclaren D" first="Donald G." last="Mclaren">Donald G. Mclaren</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Xu, Guofan" sort="Xu, Guofan" uniqKey="Xu G" first="Guofan" last="Xu">Guofan Xu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Nickles, Robert J" sort="Nickles, Robert J" uniqKey="Nickles R" first="Robert J." last="Nickles">Robert J. Nickles</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Pyzalski, Robert" sort="Pyzalski, Robert" uniqKey="Pyzalski R" first="Robert" last="Pyzalski">Robert Pyzalski</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Dejesus, Onofre" sort="Dejesus, Onofre" uniqKey="Dejesus O" first="Onofre" last="Dejesus">Onofre Dejesus</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Brown, W Douglas" sort="Brown, W Douglas" uniqKey="Brown W" first="W. Douglas" last="Brown">W. Douglas Brown</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="614">614</biblScope><biblScope unit="page" to="620">620</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D04619D25D6B2071F8A6C7A36FA7EEAAF0A328C7</idno><idno type="DOI">10.1002/mds.23503</idno><idno type="ArticleID">MDS23503</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fluorodopa positron emission tomography</term><term>Parkinson's disease</term><term>aging</term><term>disease progression</term><term>gender</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Rate of decline in 6‐L‐[18F]fluorodopa (FDOPA) uptake within the striatum has been reported as showing regional differences in Parkinson's disease (PD). Methods:: We acquired longitudinal brain FDOPA positron emission tomography (PET) studies in 26 PD subjects and 11 controls over 4.5 years. We analyzed both spatially normalized voxel‐wise maps of radiotracer influx (Kocc) and average Kocc values for six non‐overlapping volumes of interest (VOIs) encompassing the striatum. Results:: The voxel‐wise analysis showed that in PD, FDOPA Kocc decline spanned the striatum but was greatest in the posterior putamen ipsilateral and anterior putamen contralateral to initial symptoms. The VOI approached showed that absolute rates of Kocc decline were significantly greater in PD than control subjects, but that the slope of decline did not differ between subregions. In PD, ratios of uptake between subregions did not change during the study with the exception of the ipsilateral putamen/caudate ratio. Decline rates were marginally greater during earlier time segments. Both male gender and advancing age were associated with lower baseline FDOPA uptake, but no difference in decline rates. VOI Kocc values were significantly correlated with disease duration, but only moderately correlated with clinical measures. Discussion:: We conclude that FDOPA uptake in subregions of the striatum is strongly correlated with disease duration and age, and declines approximately equally from symptom onset in PD. This implies that in idiopathic PD, relative preservation of uptake in the anterior striatum reflects a delay in pathologic involvement of nigrostriatal projections to this region. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Gallagher, Catherine L" sort="Gallagher, Catherine L" uniqKey="Gallagher C" first="Catherine L." last="Gallagher">Catherine L. Gallagher</name></region><name sortKey="Bendlin, Barbara B" sort="Bendlin, Barbara B" uniqKey="Bendlin B" first="Barbara B." last="Bendlin">Barbara B. Bendlin</name><name sortKey="Bendlin, Barbara B" sort="Bendlin, Barbara B" uniqKey="Bendlin B" first="Barbara B." last="Bendlin">Barbara B. Bendlin</name><name sortKey="Brown, W Douglas" sort="Brown, W Douglas" uniqKey="Brown W" first="W. Douglas" last="Brown">W. Douglas Brown</name><name sortKey="Chung, Moo K" sort="Chung, Moo K" uniqKey="Chung M" first="Moo K." last="Chung">Moo K. Chung</name><name sortKey="Chung, Moo K" sort="Chung, Moo K" uniqKey="Chung M" first="Moo K." last="Chung">Moo K. Chung</name><name sortKey="Dejesus, Onofre" sort="Dejesus, Onofre" uniqKey="Dejesus O" first="Onofre" last="Dejesus">Onofre Dejesus</name><name sortKey="Gallagher, Catherine L" sort="Gallagher, Catherine L" uniqKey="Gallagher C" first="Catherine L." last="Gallagher">Catherine L. Gallagher</name><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E." last="Holden">James E. Holden</name><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C." last="Johnson">Sterling C. Johnson</name><name sortKey="Johnson, Sterling C" sort="Johnson, Sterling C" uniqKey="Johnson S" first="Sterling C." last="Johnson">Sterling C. Johnson</name><name sortKey="Mclaren, Donald G" sort="Mclaren, Donald G" uniqKey="Mclaren D" first="Donald G." last="Mclaren">Donald G. Mclaren</name><name sortKey="Mclaren, Donald G" sort="Mclaren, Donald G" uniqKey="Mclaren D" first="Donald G." last="Mclaren">Donald G. Mclaren</name><name sortKey="Nickles, Robert J" sort="Nickles, Robert J" uniqKey="Nickles R" first="Robert J." last="Nickles">Robert J. Nickles</name><name sortKey="Oakes, Terrence R" sort="Oakes, Terrence R" uniqKey="Oakes T" first="Terrence R." last="Oakes">Terrence R. Oakes</name><name sortKey="Pyzalski, Robert" sort="Pyzalski, Robert" uniqKey="Pyzalski R" first="Robert" last="Pyzalski">Robert Pyzalski</name><name sortKey="Xu, Guofan" sort="Xu, Guofan" uniqKey="Xu G" first="Guofan" last="Xu">Guofan Xu</name><name sortKey="Xu, Guofan" sort="Xu, Guofan" uniqKey="Xu G" first="Guofan" last="Xu">Guofan Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000175 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000175 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D04619D25D6B2071F8A6C7A36FA7EEAAF0A328C7
|texte= Rate of 6‐[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |